The logo shows the crystal structure of the catalytic domain of USP9X
Some say research needs passion (fire),
Some say perseverance (ice).
From what I've tasted of desire,
I hold with those who favour fire.
But if it had to spark forever,
Fire or ice alone would not suffice.
— Modified from Robert Frost's Fire and Ice
UNDERSTAND LIFE AT ATOMIC LEVEL
Biochemistry is an extreme type of reductionism, trying to understand life at a molecular level. We use structural biology, including X-ray crystallography and solution nuclear magnetic resonance (NMR) spectroscopy, and biochemical/biophysical techniques to study biomacromolecular interactions, also known as molecular recognition. More specifically, we are interested in the molecular mechanism of the regulatory enzymes (with a focus on E3 ligases and deubiquitinases) of ubiquitination, a critical post-translational modification, and small GTPases cell signalling involved in stress response and of disease relevance. We are also interested in developing tool molecules, either small molecule compounds or biological binders (for example, ubiquitin variants), to study and regulate the activities of these enzymes.
We are always looking for talented, self-motivated individuals to join the group. Please read the expectation of future students before contacting me at ytong (at) uwindsor.ca to discuss opportunities.